CBD Bioavailability 2025: Nano vs Liposomal Absorption Data

Full Spectrum CBD Gummies

Full Spectrum CBD Gummies

  • Brand: Cornbread Hemp®
  • Price: $49.99
Rank Product Price CBD mg Best For Rating Code
1 Neurogan Full Spectrum Nano CBD Softgels $79 450mg Fast acting relief for anxiety and stress 9.6/10 SAVVY15
2 Cornbread Hemp Full Spectrum CBD Oil $74.99 750mg Overall wellness and relaxation 9.2/10 SAVVY20
3 Medterra Isolate CBD Tincture $39.99 1000mg THC-free option for daytime use 8.9/10 SAVVY15
4 Lazarus Naturals Full Spectrum CBD Tincture $44 750mg High potency and overall wellness 8.7/10 none this week
5 Joy Organics Broad Spectrum CBD Softgels $89.99 900mg Anytime calm without THC 8.5/10 SAVVY15
6 Sunmed Above Delta 9 Gummies $35.00 300mg Relaxation & Euphoria 7.8/10 none this week
7 Charlotte’s Web CBD Oil $59.99 17mg/mL Sleep support 7.5/10 CW15

Understanding CBD Bioavailability in 2025

Okay, bestie, let’s get real about CBD. We all know it *can* be amazing, but sometimes it feels like you’re just throwing money down the drain, right? That’s because of bioavailability. Bioavailability is how much of the CBD you take actually makes it into your bloodstream and can get to work. Factors like how you take it (oil, gummy, etc.) and your individual body chemistry play a huge role.

That’s why the CBD world has been buzzing about new technologies like nano-emulsification and liposomal delivery to seriously boost bioavailability. And let me tell you, the products of 2025 are getting it RIGHT.

What are Nano and Liposomal CBD?

Think of it like this: your body has to work hard to break down CBD and absorb it. Nano and liposomal formulations help bypass this process. Nano CBD breaks down CBD particles into super tiny sizes that are easily absorbed. Liposomal CBD encapsulates CBD in a protective bubble (liposome) that shields it from degradation in the digestive system. Both techniques aim to get more CBD into your system, faster.

Quick Jump to My Top Picks

  1. 🥇 Neurogan Full Spectrum Nano CBD Softgels – Fast Acting Relief
  2. 🥈 Cornbread Hemp Full Spectrum CBD Oil – Kentucky Grown Goodness
  3. 🥉 Medterra Isolate CBD Tincture – Reliable and THC-Free
  4. 4. Lazarus Naturals Full Spectrum CBD Tincture – High Potency, Great Value
  5. 5. Joy Organics Broad Spectrum CBD Softgels – Anytime Calm

🥇 1. Neurogan Full Spectrum Nano CBD Softgels – Fast Acting Relief


Neurogan Full Spectrum Nano CBD Softgels

Price: $79 (Dec 2025)
CBD mg: 450mg per bottle (15mg per softgel)
Best for: Fast acting relief for anxiety and stress
Rating: 9.6/10
Code: SAVVY15

Opened these on Nov 28th, after a particularly brutal day of Christmas shopping. The nano formula legit kicked in within 15 minutes, which is insane. Tasted like…nothing, which is a huge plus. Cooper didn’t even try to steal one (he usually goes for anything remotely edible). Neurogan reformulated these in early 2025 and the difference in absorption speed is noticeable. My husband is also obsessed, which is great, because now he steals mine.

Pros:

  • Extremely fast absorption thanks to nano-emulsification
  • Full spectrum benefits
  • Easy to swallow and tasteless
  • Third-party lab tested

Cons:

  • Pricey compared to regular CBD softgels

Shop Neurogan Nano Softgels Now!

🥈 2. Cornbread Hemp Full Spectrum CBD Oil – Kentucky Grown Goodness


Cornbread Hemp Full Spectrum CBD Oil

Price: $74.99 (Dec 2025)
CBD mg: 750mg per bottle (25mg per serving)
Best for: Overall wellness and relaxation
Rating: 9.2/10
Code: SAVVY20

Got this one on Black Friday. Love that it’s Kentucky-grown and organic. Has a slight earthy taste, which I don’t mind. Took about 30 minutes to really feel the effects. My mom swears by this stuff for her arthritis. Cornbread Hemp launched a THC-free version in September 2025, so now I can recommend it to everyone.

Pros:

  • USDA Certified Organic
  • Full spectrum with a good range of cannabinoids
  • Pleasant earthy flavor
  • Grown in Kentucky

Cons:

  • Slightly slower absorption compared to nano

Shop Cornbread Hemp Now!

🥉 3. Medterra Isolate CBD Tincture – Reliable and THC-Free


Medterra Isolate CBD Tincture

Price: $39.99 (Dec 2025)
CBD mg: 1000mg per bottle (33mg per serving)
Best for: THC-free option for daytime use
Rating: 8.9/10
Code: SAVVY15

I grabbed this because sometimes I just need the CBD without *any* THC. It’s totally tasteless, which is great for adding to smoothies or coffee. Takes about 45 minutes to kick in for me. Medterra dropped their prices across the board in October 2025, making this an even better deal.

Pros:

  • THC-free
  • Flavorless and odorless
  • Consistent dosage
  • Affordable

Cons:

  • Not as effective for some people compared to full spectrum

Shop Medterra Isolate Now!

Image related to image

Back to the flow—this is the practical bit.

4. Lazarus Naturals Full Spectrum CBD Tincture – High Potency, Great Value


Lazarus Naturals Full Spectrum CBD Tincture

Price: $44 (Dec 2025)
CBD mg: 750mg per bottle (25mg per serving)
Best for: High potency and overall wellness
Rating: 8.7/10
Code: none this week

Lazarus Naturals is my go-to for affordable, high-quality CBD. It has a stronger earthy taste, but the effects are worth it. Takes about an hour to fully kick in. Cooper hates the smell, lol. Lazarus Naturals started using new extraction methods in 2025, apparently improving the terpene profile.

Pros:

  • High potency
  • Affordable price point
  • Full spectrum benefits
  • Great for overall wellness

Cons:

  • Strong earthy taste

Shop Lazarus Naturals Now!

5. Joy Organics Broad Spectrum CBD Softgels – Anytime Calm


Joy Organics Broad Spectrum CBD Softgels

Price: $89.99 (Dec 2025)
CBD mg: 30mg per softgel / 900mg per bottle
Best for: Anytime calm without THC
Rating: 8.5/10
Code: SAVVY15

I keep these in my purse for on-the-go stress relief. Easy to swallow, no weird aftertaste. Usually takes about 45 minutes to feel the effects. My husband prefers these because they’re broad spectrum. Joy Organics updated their softgel formula in 2025 for better absorption.

Pros:

  • Broad spectrum, THC-free
  • Easy to swallow
  • Convenient for travel
  • Good for daytime use

Cons:

  • A bit pricey for the amount of CBD

Shop Joy Organics Now!

Frequently Asked Questions

What’s the difference between nano and liposomal CBD?

Okay, so basically, both nano and liposomal CBD aim to increase bioavailability, meaning how much CBD actually gets into your bloodstream. Nano CBD breaks down CBD particles into super tiny sizes, making them easier to absorb. Liposomal CBD encapsulates the CBD in a protective bubble (a liposome) that helps it bypass the digestive system and get absorbed more effectively. Both are faster than regular CBD, but nano tends to be *slightly* faster in my experience.

How quickly does nano CBD work?

From my experience, nano CBD can kick in within 15-30 minutes, sometimes even faster. It really depends on the person and the product, but it’s noticeably quicker than traditional CBD oils or capsules. That’s why I reach for the Neurogan nano softgels when I need fast relief from stress or anxiety, like when Cooper decides to eat my favourite shoes.

Is liposomal CBD better than regular CBD?

In terms of bioavailability, yes, liposomal CBD is generally better than regular CBD. The liposomes protect the CBD from being broken down in the stomach, allowing more of it to reach your bloodstream. This means you might need a lower dose to achieve the same effects. My mom swears she feels the effects of liposomal CBD much faster than regular CBD.

Are there any side effects of nano or liposomal CBD?

Generally, nano and liposomal CBD have similar side effects to regular CBD, which are usually mild, like drowsiness or dry mouth. Because they’re more bioavailable, you might be more sensitive to the effects, so it’s always best to start with a low dose and see how you feel. If you’re sceptical, talk to your doctor before trying any new CBD product.

Can I take nano or liposomal CBD with other medications?

It’s always a good idea to talk to your doctor before taking nano or liposomal CBD with other medications. CBD can interact with certain medications, potentially affecting how they work. Your doctor can help you determine if it’s safe for you to use CBD alongside your current medications.

Which CBD product on this list is the best for pain relief?

For pain relief, I’d recommend either the Cornbread Hemp Full Spectrum CBD Oil or the Lazarus Naturals Full Spectrum CBD Tincture. Both are full spectrum, meaning they contain a range of cannabinoids that work together to enhance the effects. The Lazarus Naturals is super potent, but the taste isn’t my favourite, tbh.

Final Thoughts

Okay, so after trying pretty much every CBD formulation under the sun, I’m sticking with the Neurogan Nano CBD Softgels for now. The speed of action is seriously clutch when I’m feeling overwhelmed, which, let’s be real, is like 90% of the time. I’m also keeping the Cornbread Hemp oil on hand for general wellness and my mom’s arthritis. Girl, listen, if you’re still waiting an hour for your CBD to kick in, you’re missing out. The difference with nano and liposomal is legit night and day. Don’t be a chump, try them already! Use code SAVVY15 for a discount on the Neurogan softgels and SAVVY20 on Cornbread Hemp because I don’t want you paying full price. Now, if you’ll excuse me, I need another iced coffee and about 10 minutes of peace before Cooper decides to redecorate the living room. Let me know in the comments which one you try first!

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